Gene

Irk1

Species
Drosophila melanogaster
Symbol
Irk1
Name
Inwardly rectifying potassium channel 1
Synonyms
  • CG13836
  • CG44159
Biotype
protein coding gene
Automated Description
Enables inward rectifier potassium channel activity. Involved in several processes, including locomotor rhythm; potassium ion transport; and wing disc development. Located in membrane. Is expressed in several structures, including adult head; embryonic/larval corpus cardiacum; epithelial tube; ganglia; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including EAST syndrome; autosomal recessive nonsyndromic deafness 4; glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Orthologous to several human genes including KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) and KCNJ9 (potassium inwardly rectifying channel subfamily J member 9).
FB Description
Inwardly rectifying potassium channel 1 (Irk1) encodes a K[+] channel involved in transepithelial ion transport in the renal tubule and in regulating excitability of the LNv subset of circadian pacemaker neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11767
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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23.170M23.172M23.174M23.176M23.178M23.180M23.182M23.184M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions