Enables inward rectifier potassium channel activity. Involved in several processes, including locomotor rhythm; potassium ion transport; and wing disc development. Located in membrane. Is expressed in several structures, including adult head; embryonic/larval corpus cardiacum; epithelial tube; ganglia; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including EAST syndrome; autosomal recessive nonsyndromic deafness 4; glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Orthologous to several human genes including KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) and KCNJ9 (potassium inwardly rectifying channel subfamily J member 9).
FB Description
Inwardly rectifying potassium channel 1 (Irk1) encodes a K[+] channel involved in transepithelial ion transport in the renal tubule and in regulating excitability of the LNv subset of circadian pacemaker neurons.