Enables tumor necrosis factor receptor superfamily binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of signal transduction; protein K63-linked ubiquitination; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in eye disc posterior to the morphogenetic furrow and organism. Orthologous to human TRAF6 (TNF receptor associated factor 6).
FB Description
TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.