Gene

Traf6

Species
Drosophila melanogaster
Symbol
Traf6
Name
TNF-receptor-associated factor 6
Synonyms
  • CG10961
  • dtraf2
Biotype
protein coding gene
Automated Description
Enables tumor necrosis factor receptor superfamily binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of signal transduction; protein K63-linked ubiquitination; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in eye disc posterior to the morphogenetic furrow and organism. Orthologous to human TRAF6 (TNF receptor associated factor 6).
FB Description
TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10131
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
8.1550M8.1555M8.1560M8.1565M8.1570M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions