Involved in delamination; epithelial to mesenchymal transition; and imaginal disc-derived wing expansion. Predicted to be active in nucleus. Is expressed in several structures, including circular visceral muscle fiber; clypeo-labral primordium; imaginal disc; larval foregut atrium; and ventral epidermis primordium. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin zinc finger protein 1) and BNC2 (basonuclin zinc finger protein 2).
FB Description
disco-related (disco-r) encodes a C2H2 zinc-finger transcription factor. It has known roles in larval and adult appendage development, where it appears to control proximal-distal fate in ventral appendages including adult legs, antenna, and larval and adult mouthparts.