Gene

cv-c

Species
Drosophila melanogaster
Symbol
cv-c
Name
crossveinless c
Synonyms
  • CG14845
  • CG14846
Biotype
protein coding gene
Automated Description
Enables GTPase activator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and open tracheal system development. Located in basolateral plasma membrane. Is expressed in several structures, including brain; fan-shaped body; imaginal disc; large field neurons; and wing vein. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8).
FB Description
crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12659
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
14.40M14.41M14.42M14.43M14.44M14.45M14.46M14.47M14.48M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions