Enables GTPase activator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and open tracheal system development. Located in basolateral plasma membrane. Is expressed in several structures, including brain; fan-shaped body; imaginal disc; large field neurons; and wing vein. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8).
FB Description
crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis.