Version: 8.0.0Date: Tue Jan 28 2025
Gene
scb
- Species
- Drosophila melanogaster
- Symbol
- scb
- Name
- scab
- Synonyms
- &agr-PS3
- alpha Position-Specific antigen 3
- Biotype
- protein coding gene
- Automated Description
- Enables protein heterodimerization activity. Involved in several processes, including behavioral response to ethanol; dorsal trunk growth, open tracheal system; and heart development. Located in apical plasma membrane; basal plasma membrane; and cytoplasm. Part of integrin complex. Is expressed in several structures, including Kenyon cell; epithelium; follicle cell; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to several human genes including ITGA9 (integrin subunit alpha 9).
- FB Description
- scab (scb) encodes the alpha-PS3 Integrin, believed to dimerise with mys and possibly Itgbn. It regulates adhesion, signalling, polarity and cell migration. Genetic interaction with Laminin genes implicates them as extracellular matrix ligands.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23220
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr2R:15248784...15258498 + (9.71 kb)
- Assembly version
- R6
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.