Gene

unc-45

Species
Drosophila melanogaster
Symbol
unc-45
Name
uncoordinated 45
Synonyms
  • CG2708
  • DmUnc-45
Biotype
protein coding gene
Automated Description
Predicted to enable Hsp90 protein binding activity. Involved in several processes, including cellular response to heat; chaperone-mediated protein folding; and myosin filament assembly. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; dorsal vessel; muscle cell; and somatic muscle primordium.
FB Description
uncoordinated 45 (unc-45) encodes a protein that binds the product of Hsp83 and myosin, and may may serve as a scaffold for their interaction. It is required for normal myosin accumulation and appears to play a role in myosin folding and/or protection from stress.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45994
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
8.0335M8.0340M8.0345M8.0350M8.0355M8.0360M8.0365M8.0370M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions