Gene

RGS4

Species
Homo sapiens
Symbol
RGS4
Name
regulator of G protein signaling 4
Synonyms
  • DKFZp761F1924
  • MGC2124
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity; GTPase activity; and calmodulin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Part of cytoplasm and nucleus.
RGD Description
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10845
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            163.069M163.070M163.071M163.072M163.073M163.074M163.075M163.076M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            RGS4 molecule type
            Interactor gene
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              Genetic Interactions

              RGS4 role
              RGS4 genetic perturbation
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