Gene

RHEB

Species
Homo sapiens
Symbol
RHEB
Name
Ras homolog, mTORC1 binding
Synonyms
  • GTP-binding protein Rheb
  • MGC111559
Biotype
protein coding gene
Automated Description
Enables several functions, including guanyl ribonucleotide binding activity; magnesium ion binding activity; and protein serine/threonine kinase activator activity. Involved in cellular response to nutrient levels; positive regulation of TORC1 signaling; and regulation of type B pancreatic cell development. Located in extracellular exosome. Is active in endomembrane system; lysosomal membrane; and postsynaptic density.
RGD Description
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24070
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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151.470M151.475M151.480M151.485M151.490M151.495M151.500M151.505M151.510M151.515M151.520M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions