Enables receptor ligand activity and semaphorin receptor binding activity. Involved in several processes, including gonadotrophin-releasing hormone neuronal migration to the hypothalamus; negative regulation of neuron apoptotic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membrane.
RGD Description
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]