SET domain bifurcated histone lysine methyltransferase 1
Synonyms
ERG-associated protein with a SET domain, ESET
ERG-associated protein with SET domain
Biotype
protein coding gene
Automated Description
Enables histone H3K9 trimethyltransferase activity and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation. Located in cytoplasm and nucleoplasm. Is active in nucleus. Implicated in autistic disorder and lung cancer. Biomarker of Huntington's disease; high grade glioma; melanoma; prostate cancer; and schizophrenia.
RGD Description
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]