Gene

SH3GLB1

Species
Homo sapiens
Symbol
SH3GLB1
Name
SH3 domain containing GRB2 like, endophilin B1
Synonyms
  • Bax-interacting factor 1
  • Bif-1
Biotype
protein coding gene
Automated Description
Enables protein homodimerization activity. Involved in several processes, including autophagic cell death; cellular response to amino acid starvation; and positive regulation of cellular component organization. Located in autophagosome membrane; cytosol; and midbody. Part of protein-containing complex.
RGD Description
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14167
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
86.705M86.710M86.715M86.720M86.725M86.730M86.735M86.740M86.745M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions