Gene

VPS4B

Species
Homo sapiens
Symbol
VPS4B
Name
vacuolar protein sorting 4 homolog B
Synonyms
  • cell migration-inducing 1
  • cell migration-inducing gene 1 protein
Biotype
protein coding gene
Automated Description
Enables ATP hydrolysis activity and protein homodimerization activity. Involved in several processes, including proteolysis involved in protein catabolic process; regulation of cell cycle process; and regulation of exosomal secretion. Acts upstream of or within endosomal transport. Located in several cellular components, including Flemming body; endosome membrane; and microtubule cytoskeleton.
RGD Description
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23074
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            63.390M63.395M63.400M63.405M63.410M63.415M63.420M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            VPS4B molecule type
            Interactor gene
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              Genetic Interactions

              VPS4B role
              VPS4B genetic perturbation
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