Enables high-affinity L-glutamate transmembrane transporter activity. Involved in amino acid import across plasma membrane and protein homotrimerization. Located in cell surface; membrane raft; and plasma membrane. Part of membrane protein complex. Is active in presynaptic membrane. Implicated in developmental and epileptic encephalopathy 41. Biomarker of Huntington's disease and amyotrophic lateral sclerosis.
RGD Description
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]