Version: 8.0.0
Date: Tue Jan 28 2025
SLC24A2
Homo sapiensHGNC:10976
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

SLC24A2

Species
Homo sapiens
Symbol
SLC24A2
Name
solute carrier family 24 member 2
Synonyms
  • FLJ45149
  • Na(+)/K(+)/Ca(2+)-exchange protein 2
Biotype
protein coding gene
Automated Description
Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion import across plasma membrane; potassium ion transmembrane transport; and sodium ion transmembrane transport. Acts upstream of or within intracellular calcium ion homeostasis and monoatomic ion transmembrane transport. Located in plasma membrane.
RGD Description
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10846
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            SLC24A2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              SLC24A2 role
              SLC24A2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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