Gene

SLC24A2

Species
Homo sapiens
Symbol
SLC24A2
Name
solute carrier family 24 member 2
Synonyms
  • FLJ45149
  • Na(+)/K(+)/Ca(2+)-exchange protein 2
Biotype
protein coding gene
Automated Description
Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion import across plasma membrane; potassium ion transmembrane transport; and sodium ion transmembrane transport. Acts upstream of or within intracellular calcium ion homeostasis and monoatomic ion transmembrane transport. Located in plasma membrane.
RGD Description
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10846
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
Other Sources
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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            SLC24A2 molecule type
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              Genetic Interactions

              SLC24A2 role
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