Gene

SLC27A2

Species
Homo sapiens
Symbol
SLC27A2
Name
solute carrier family 27 member 2
Synonyms
  • ACSVL1
  • arachidonate--CoA ligase
Biotype
protein coding gene
Automated Description
Enables CoA-ligase activity; enzyme binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in bile acid biosynthetic process and fatty acid metabolic process. Located in endoplasmic reticulum lumen; endoplasmic reticulum membrane; and peroxisomal membrane.
RGD Description
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43107
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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50.185M50.190M50.195M50.200M50.205M50.210M50.215M50.220M50.225M50.230M50.235M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions