Gene

SLC30A4

Species
Homo sapiens
Symbol
SLC30A4
Name
solute carrier family 30 member 4
Synonyms
  • probable proton-coupled zinc antiporter SLC30A4
  • solute carrier family 30 (zinc transporter), member 4
Biotype
protein coding gene
Automated Description
Enables zinc ion transmembrane transporter activity. Involved in response to toxic substance and zinc ion import into lysosome. Located in late endosome. Biomarker of prostate carcinoma in situ.
RGD Description
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11562
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
45.480M45.485M45.490M45.495M45.500M45.505M45.510M45.515M45.520M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions