Gene

SLC5A1

Species
Homo sapiens
Symbol
SLC5A1
Name
solute carrier family 5 member 1
Synonyms
  • D22S675
  • high affinity sodium-glucose cotransporter
Biotype
protein coding gene
Automated Description
Enables alpha-glucoside transmembrane transporter activity; carbohydrate:monoatomic cation symporter activity; and water transmembrane transporter activity. Involved in several processes, including alpha-glucoside transport; import across plasma membrane; and transepithelial water transport. Located in apical plasma membrane; early endosome; and perinuclear region of cytoplasm. Implicated in glucose-galactose malabsorption.
RGD Description
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11819
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
32.05M32.06M32.07M32.08M32.09M32.10M32.11M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions