Predicted to enable L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport and L-leucine transport. Located in basolateral plasma membrane. Implicated in lysinuric protein intolerance.
RGD Description
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]