Gene

SLC7A7

Species
Homo sapiens
Symbol
SLC7A7
Name
solute carrier family 7 member 7
Synonyms
  • LAT3
  • LPI
Biotype
protein coding gene
Automated Description
Predicted to enable L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport and L-leucine transport. Located in basolateral plasma membrane. Implicated in lysinuric protein intolerance.
RGD Description
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11785
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
22.78M22.79M22.80M22.81M22.82M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions