Version: 8.0.0Date: Tue Jan 28 2025
Gene
STAT3
- Species
- Homo sapiens
- Symbol
- STAT3
- Name
- signal transducer and activator of transcription 3
- Synonyms
- acute-phase response factor
- ADMIO
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA sequestering activity; and nucleic acid binding activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Located in chromatin; cytosol; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Churg-Strauss syndrome; gastrointestinal system cancer (multiple); kidney cancer (multiple); lung disease (multiple); and lymphoma (multiple).
- RGD Description
- The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11801
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr17:42313324...42388568 - (75.24 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.