Enables flavonol 3-sulfotransferase activity and steroid sulfotransferase activity. Involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; estrogen catabolic process; and ethanol catabolic process. Acts upstream of or within sulfation. Located in cytosol and nuclear membrane. Implicated in breast cancer and endometrial cancer.
RGD Description
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]