Version: 8.0.0
Date: Tue Jan 28 2025
BUB3
Homo sapiensHGNC:1151
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

BUB3

Species
Homo sapiens
Symbol
BUB3
Name
BUB3 mitotic checkpoint protein
Synonyms
  • BUB3 budding uninhibited by benzimidazoles 3 homolog
  • BUB3L
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin binding activity. Involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Located in kinetochore and nucleoplasm. Part of mitotic checkpoint complex.
RGD Description
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10971
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Alleles and Variants

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions