Gene

TARBP2

Species
Homo sapiens
Symbol
TARBP2
Name
TARBP2 subunit of RISC loading complex
Synonyms
  • LOQS
  • RISC-loading complex subunit TARBP2
Biotype
protein coding gene
Automated Description
Enables several functions, including RNA binding activity; protein homodimerization activity; and protein sequestering activity. Contributes to pre-miRNA binding activity. Involved in several processes, including negative regulation of gene expression; positive regulation of viral genome replication; and regulation of defense response. Located in cytoplasm and nuclear body. Part of RISC complex and RISC-loading complex.
RGD Description
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46205
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
53.5010M53.5015M53.5020M53.5025M53.5030M53.5035M53.5040M53.5045M53.5050M53.5055M53.5060M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions