Gene

TARS1

Species
Homo sapiens
Symbol
TARS1
Name
threonyl-tRNA synthetase 1
Synonyms
  • MGC9344
  • TARS
Biotype
protein coding gene
Automated Description
Enables several functions, including ATP binding activity; threonine-tRNA ligase activity; and zinc ion binding activity. Involved in threonyl-tRNA aminoacylation. Located in extracellular exosome. Implicated in nonphotosensitive trichothiodystrophy 7.
RGD Description
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11451
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
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    33.445M33.450M33.455M33.460M33.465M

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions