Version: 8.0.0
Date: Tue Jan 28 2025
TCF7L2
Homo sapiensHGNC:11641
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

TCF7L2

Species
Homo sapiens
Symbol
TCF7L2
Name
transcription factor 7 like 2
Synonyms
  • HMG box transcription factor 4
  • hTCF-4
Biotype
protein coding gene
Automated Description
Enables several functions, including armadillo repeat domain binding activity; beta-catenin binding activity; and gamma-catenin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of protein localization; and regulation of DNA-templated transcription. Located in chromatin and nucleoplasm. Part of beta-catenin-TCF7L2 complex and protein-DNA complex. Implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Biomarker of type 2 diabetes mellitus.
RGD Description
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10373
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          TCF7L2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            TCF7L2 role
            TCF7L2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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