Gene

VPS72

Species
Homo sapiens
Symbol
VPS72
Name
vacuolar protein sorting 72 homolog
Synonyms
  • CFL1
  • Swc2
Biotype
protein coding gene
Automated Description
Enables histone binding activity and histone chaperone activity. Involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and transcription initiation-coupled chromatin remodeling. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex and nucleosome.
RGD Description
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13275
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
151.178M151.180M151.182M151.184M151.186M151.188M151.190M151.192M151.194M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions