Gene

TGFB1I1

Species
Homo sapiens
Symbol
TGFB1I1
Name
transforming growth factor beta 1 induced transcript 1
Synonyms
  • androgen receptor coactivator 55 kDa protein
  • androgen receptor coactivator ARA55
Biotype
protein coding gene
Automated Description
Enables several functions, including I-SMAD binding activity; Roundabout binding activity; and nuclear androgen receptor binding activity. Involved in positive regulation of epithelial to mesenchymal transition; positive regulation of macromolecule metabolic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol; focal adhesion; and intracellular membrane-bounded organelle.
RGD Description
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24214
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            31.472M31.473M31.474M31.475M31.476M31.477M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            TGFB1I1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              TGFB1I1 role
              TGFB1I1 genetic perturbation
              Interactor gene
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