Enables identical protein binding activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including keratinocyte differentiation; peptide cross-linking; and positive regulation of keratinocyte proliferation. Located in membrane. Implicated in autosomal recessive congenital ichthyosis 1.
RGD Description
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]