Version: 8.0.0Date: Tue Jan 28 2025
Gene
TLR2
- Species
- Homo sapiens
- Symbol
- TLR2
- Name
- toll like receptor 2
- Synonyms
- CD282
- TIL4
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including amyloid-beta binding activity; lipopolysaccharide binding activity; and peptidoglycan binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of defense response. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and response to molecule of bacterial origin. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Part of Toll-like receptor 1-Toll-like receptor 2 protein complex and Toll-like receptor 2-Toll-like receptor 6 protein complex. Implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); middle ear disease (multiple); and nose disease (multiple).
- RGD Description
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24365
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr4:153684050...153710637 + (26.59 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.