Enables identical protein binding activity and protease binding activity. Involved in TRAIL-activated apoptotic signaling pathway and cellular response to mechanical stimulus. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is active in plasma membrane raft. Implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Biomarker of breast ductal carcinoma and renal cell carcinoma.
RGD Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]