Gene

TNFRSF10A

Species
Homo sapiens
Symbol
TNFRSF10A
Name
TNF receptor superfamily member 10a
Synonyms
  • APO2
  • CD261
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity and protease binding activity. Involved in TRAIL-activated apoptotic signaling pathway and cellular response to mechanical stimulus. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is active in plasma membrane raft. Implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Biomarker of breast ductal carcinoma and renal cell carcinoma.
RGD Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46330
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
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    23.195M23.200M23.205M23.210M23.215M23.220M23.225M

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions