Version: 8.0.0
Date: Tue Jan 28 2025
TNFRSF11B
Homo sapiensHGNC:11909
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

TNFRSF11B

Species
Homo sapiens
Symbol
TNFRSF11B
Name
TNF receptor superfamily member 11b
Synonyms
  • MGC29565
  • OCIF
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine activity and signaling receptor activity. Predicted to be involved in signal transduction and skeletal system development. Predicted to act upstream of or within several processes, including negative regulation of odontogenesis of dentin-containing tooth; negative regulation of osteoclast differentiation; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in extracellular space. Part of receptor complex. Implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Biomarker of several diseases, including artery disease (multiple); end stage renal disease; hereditary arterial and articular multiple calcification syndrome; lupus nephritis; and type 2 diabetes mellitus.
RGD Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23097
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          TNFRSF11B molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            TNFRSF11B role
            TNFRSF11B genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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