Gene

TNFSF8

Species
Homo sapiens
Symbol
TNFSF8
Name
TNF superfamily member 8
Synonyms
  • CD153
  • CD153 antigen
Biotype
protein coding gene
Automated Description
Predicted to enable signaling receptor binding activity. Predicted to be involved in CD8-positive, alpha-beta T cell differentiation. Predicted to act upstream of or within defense response to Gram-positive bacterium and positive regulation of transcription by RNA polymerase II. Predicted to be located in plasma membrane.
RGD Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR32163
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
114.895M114.900M114.905M114.910M114.915M114.920M114.925M114.930M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions