Gene

TRPM2

Species
Homo sapiens
Symbol
TRPM2
Name
transient receptor potential cation channel subfamily M member 2
Synonyms
  • EREG1
  • estrogen-responsive element-associated gene 1 protein
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity; intracellularly gated calcium channel activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including cellular response to hydrogen peroxide; monoatomic cation transmembrane transport; and protein homotetramerization. Located in lysosome and plasma membrane.
RGD Description
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13800
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
44.36M44.37M44.38M44.39M44.40M44.41M44.42M44.43M44.44M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions