transient receptor potential cation channel subfamily M member 2
Synonyms
EREG1
estrogen-responsive element-associated gene 1 protein
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity; intracellularly gated calcium channel activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including cellular response to hydrogen peroxide; monoatomic cation transmembrane transport; and protein homotetramerization. Located in lysosome and plasma membrane.
RGD Description
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]