Gene

TYMS

Species
Homo sapiens
Symbol
TYMS
Name
thymidylate synthetase
Synonyms
  • DKCD
  • HST422
Biotype
protein coding gene
Automated Description
Enables mRNA regulatory element binding translation repressor activity; sequence-specific mRNA binding activity; and thymidylate synthase activity. Involved in several processes, including dTMP biosynthetic process; negative regulation of translation; and tetrahydrofolate interconversion. Located in mitochondrial inner membrane; mitochondrial matrix; and nucleus. Implicated in several diseases, including abdominal aortic aneurysm; digenic dyskeratosis congenita; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis.
RGD Description
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11548
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions