Version: 8.0.0Date: Tue Jan 28 2025
Gene
UBE2L3
- Species
- Homo sapiens
- Symbol
- UBE2L3
- Name
- ubiquitin conjugating enzyme E2 L3
- Synonyms
- E2 ubiquitin-conjugating enzyme L3
- E2-F1
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activator activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of ubiquitin-protein transferase activity; and protein K11-linked ubiquitination. Located in cytoplasm and nucleus.
- RGD Description
- The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24067
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- Chr22:21549447...21624034 + (74.59 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction