Gene

UGT1A5

Species
Homo sapiens
Symbol
UGT1A5
Name
UDP glucuronosyltransferase family 1 member A5
Synonyms
  • UDP glucuronosyltransferase 1 family, polypeptide A5
  • UDP glycosyltransferase 1 family, polypeptide A5
Biotype
protein coding gene
Automated Description
Predicted to enable enzyme binding activity. Predicted to be involved in cellular glucuronidation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum.
RGD Description
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48043
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusUgt1a29 of 10YesNo  
Mus musculusUgt1a59 of 10YesNo  
Rattus norvegicusUgt1a310 of 10YesYes  
Xenopus tropicalisugt1a18 of 9YesYes   
Danio reriougt1a76 of 10YesNo  
Danio reriougt1ab6 of 10YesNo  
Drosophila melanogasterUgt35C17 of 9YesNo   
Drosophila melanogasterUgt302K17 of 9YesYes   
Drosophila melanogasterUgt49B27 of 9YesYes   
Drosophila melanogasterUgt301D16 of 9NoYes   
Drosophila melanogasterUgt35A16 of 9NoYes   
Drosophila melanogasterUgt35B16 of 9NoYes   
Drosophila melanogasterUgt35E26 of 9NoYes   
Drosophila melanogasterUgt302E16 of 9NoYes   
Drosophila melanogasterUgt303A15 of 9NoYes   
Drosophila melanogasterUgt304A15 of 9NoYes   
Drosophila melanogasterUgt36E14 of 9NoYes   
Drosophila melanogasterUgt36F14 of 9NoYes   
Drosophila melanogasterUgt36D14 of 9NoYes   
Drosophila melanogasterUgt37C14 of 9NoYes   
Drosophila melanogasterUgt303B14 of 9NoYes   
Drosophila melanogasterUgt37D13 of 9NoYes   
Drosophila melanogasterUgt37A33 of 9NoYes   
Drosophila melanogasterUgt303B33 of 9NoYes   
Drosophila melanogasterUgt37E13 of 9NoYes   
Drosophila melanogasterUgt316A13 of 9NoYes   
Caenorhabditis elegansugt-616 of 9YesNo   
Saccharomyces cerevisiaeATG262 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
UGT1A3153497958 of 8  
UGT1A4253496938 of 8  
UGT1A1352584747 of 8  
UGT1A9453477697 of 8  
UGT1A8553278687 of 8  
UGT1A10653377687 of 8  
UGT1A7753077687 of 8  
UGT1A6850979707 of 8  
UGT2B17953264446 of 8  
UGT2B41052862456 of 8  
UGT2B151152963436 of 8  
UGT2B101252663456 of 8  
UGT2B281353161446 of 8  
UGT2B111452961446 of 8  
UGT2B71553460436 of 8  
UGT2A21652061446 of 8  
UGT2A31753657436 of 8  
UGT2A11851161436 of 8  
UGT81951654346 of 8  
UGT3A12052951316 of 8  
UGT3A22154248306 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
UGT1A5 (Hsa)
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
233.72M233.73M233.74M233.75M233.76M233.77M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000002.12:g.233760332G>Cvariant
SNP
  • intron variant
NC_000002.12:g.233760446G>Avariant
SNP
  • intron variant
NC_000002.12:g.233760581T>Cvariant
SNP
  • intron variant
NC_000002.12:g.233768364G>Avariant
SNP
  • missense variant
NC_000002.12:g.233767912T>Avariant
SNP
  • missense variant
NC_000002.12:g.233772468T>Avariant
SNP
  • missense variant
NC_000002.12:g.233713736G>Cvariant
SNP
  • intron variant
NC_000002.12:g.233718617G>Avariant
SNP
  • intron variant
NC_000002.12:g.233718978C>Gvariant
SNP
  • intron variant
NC_000002.12:g.233767956T>Gvariant
SNP
  • intron variant
Showing 1 - 10 of 336 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
233.72M233.73M233.74M233.75M233.76M233.77MENST00000373414.4 (UGT1A5)NM_019078.2 (UGT1A5)ENST00000447084.1 (UGT1A12P)ENST00000456635.1 (UGT1A11P)ENST00000373450.5 (UGT1A8)NM_019076.5 (UGT1A8)ENST00000424780.1 (UGT1A13P)ENST00000344644.10 (UGT1A10)ENST00000373445.1 (UGT1A10)NM_019075.4 (UGT1A10)Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
None
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
UGT1A5 (Hsa)
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

13 interactor genes based on 13 annotations
UGT1A5 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ADAMTS2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
ARL10Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
BTN2A2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
CANXHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
DHFR2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
DIPK1AHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
DNAJC19Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
ESYT1Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
GLB1L2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
LAPTM4AHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
Showing 1 - 10 of 13 rows
per page

Genetic Interactions

No data available