Version: 8.0.0Date: Tue Jan 28 2025
Gene
USP2
- Species
- Homo sapiens
- Symbol
- USP2
- Name
- ubiquitin specific peptidase 2
- Synonyms
- 41 kDa ubiquitin-specific protease
- deubiquitinating enzyme 2
- Biotype
- protein coding gene
- Automated Description
- Enables cyclin binding activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; protein deubiquitination; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm.
- RGD Description
- This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR21646
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Sequence Feature Viewer
- Genome location
- Chr11:119355215...119381711 - (26.50 kb)
- Assembly version
- GRCh38
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