Gene

ZFYVE1

Species
Homo sapiens
Symbol
ZFYVE1
Name
zinc finger FYVE-type containing 1
Synonyms
  • DFCP1
  • double FYVE-containing protein 1
Biotype
protein coding gene
Automated Description
Enables phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including cellular response to starvation; lipid droplet formation; and positive regulation by host of viral genome replication. Located in several cellular components, including autophagosome; mitochondria-associated endoplasmic reticulum membrane contact site; and omegasome. Is extrinsic component of omegasome membrane.
RGD Description
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46624
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            72.97M72.98M72.99M73.00M73.01M73.02M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ZFYVE1 molecule type
            Interactor gene
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              Genetic Interactions

              ZFYVE1 role
              ZFYVE1 genetic perturbation
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