Gene

EI24

Species
Homo sapiens
Symbol
EI24
Name
EI24 autophagy associated transmembrane protein
Synonyms
  • ectopic P-granules autophagy protein 4 homolog
  • EPG4
Biotype
protein coding gene
Automated Description
Enables importin-alpha family protein binding activity. Acts upstream of or within negative regulation of cell growth. Located in Golgi apparatus; cytosol; and endoplasmic reticulum.
RGD Description
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21389
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
125.570M125.572M125.574M125.576M125.578M125.580M125.582M125.584M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions