Gene

RLIM

Species
Homo sapiens
Symbol
RLIM
Name
ring finger protein, LIM domain interacting
Synonyms
  • DKFZp686N06224
  • E3 ubiquitin-protein ligase RLIM
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin protein ligase activity. Involved in random inactivation of X chromosome. Located in cytosol and nucleoplasm. Implicated in Tonne-Kalscheuer syndrome.
RGD Description
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45931
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusRlim10 of 10YesYes  
Rattus norvegicusRlim9 of 10YesYes  
Xenopus laevisrlim.S1 of 1YesYes           
Xenopus laevisrlim.L1 of 1YesYes           
Xenopus tropicalisrlim7 of 9YesYes   
Danio reriorlim8 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
RNF6172752415 of 8  
RNF38253631212 of 8  
RNF4437362452 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Abnormal heart morphology
Aggressive behavior
Anxiety
Atypical behavior
Autistic behavior
Blue irides
Brachydactyly
Broad forehead
Broad thumb
Broad-based gait
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterHsap\RLIMUAS.Tag:HA
  • UASt
Showing 1 - 1 of 1 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
74.585M74.590M74.595M74.600M74.605M74.610M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions