Version: 8.0.0
Date: Tue Jan 28 2025
WDR7
Homo sapiensHGNC:13490
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

WDR7

Species
Homo sapiens
Symbol
WDR7
Name
WD repeat domain 7
Synonyms
  • KIAA0541
  • rabconnectin-3 beta
Biotype
protein coding gene
Automated Description
Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in synaptic vesicle.
RGD Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44099
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusWdr710 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusWdr710 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Xenopus laeviswdr7.L1 of 1YesYes          ☑ 
Xenopus laeviswdr7.S1 of 1YesYes          ☑ 
Xenopus tropicaliswdr75 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Drosophila melanogasterRbcn-3B9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansrbc-29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
WDR721107156355 of 8☐ ☑☐☑☑☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000018.10:g.56694662G>Tvariant
    SNP
    • missense variant
    NC_000018.10:g.56781657G>Avariant
    SNP
    • splice donor variant
    NC_000018.10:g.56672618G>Avariant
    SNP
    • missense variant
    NC_000018.10:g.56695115G>Avariant
    SNP
    • missense variant
    NC_000018.10:g.56718114G>Avariant
    SNP
    • missense variant
    NC_000018.10:g.56776857A>Gvariant
    SNP
    • missense variant
    NC_000018.10:g.56779469C>Tvariant
    SNP
    • missense variant
    NC_000018.10:g.56685981G>Avariant
    SNP
    • synonymous variant
    NC_000018.10:g.56779504C>Tvariant
    SNP
    • synonymous variant
    NC_000018.10:g.56686961C>Gvariant
    SNP
    • missense variant
    Showing 1 - 10 of 79 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    84 interactor genes based on 98 annotations
    WDR7 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		ARF3Homo sapiens
    protein
    • proximity labelling technology
    		PMID:35844135
    protein
    		ATG9AHomo sapiens
    protein
    • proximity labelling technology
    		PMID:34369648
    protein
    		ATP6V1B1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:26186194
    protein
    		ATP6V1B1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:28514442
    protein
    		ATP6V1B1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		ATP6V1B2Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		ATP6V1B2Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:35271311
    protein
    		ATP6V1E1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:35271311
    protein
    		ATP6V1FHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:35271311
    protein
    		ATP6V1G1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    Showing 1 - 10 of 64 rows
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    Genetic Interactions

    WDR7 role
    WDR7 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    unspecified role
    		ASCC3Homo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		ATP6AP1Homo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		ATP6V1G1Homo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		BNIP1Homo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		CAMLGHomo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		CHMP2AHomo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		CMASHomo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		COG3Homo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		COPEHomo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    		PMID:30033366
    unspecified role
    		EGFRHomo sapiens
    unspecified role
    negative genetic interaction (sensu BioGRID)
    • Growth abnormality
    • viability
    		PMID:31741433
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