Gene

ZBTB20

Species
Homo sapiens
Symbol
ZBTB20
Name
zinc finger and BTB domain containing 20
Synonyms
  • BTB/POZ zinc finger protein DPZF
  • dendritic cell-derived BTB/POZ zinc finger
Biotype
protein coding gene
Automated Description
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose stimulus; lipid homeostasis; and regulation of primary metabolic process. Located in nuclear body.
RGD Description
This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46105
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            114.4M114.5M114.6M114.7M114.8M114.9M115.0M115.1M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ZBTB20 molecule type
            Interactor gene
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              Genetic Interactions

              ZBTB20 role
              ZBTB20 genetic perturbation
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