Enables several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of mitophagy; protein K48-linked ubiquitination; and protein targeting to mitochondrion. Located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Part of SCF ubiquitin ligase complex. Is active in nucleus. Implicated in Parkinson's disease and Parkinson's disease 15.
RGD Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]