Gene

FBXO7

Species
Homo sapiens
Symbol
FBXO7
Name
F-box protein 7
Synonyms
  • DKFZp686B08113
  • F-box only protein 7
Biotype
protein coding gene
Automated Description
Enables several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of mitophagy; protein K48-linked ubiquitination; and protein targeting to mitochondrion. Located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Part of SCF ubiquitin ligase complex. Is active in nucleus. Implicated in Parkinson's disease and Parkinson's disease 15.
RGD Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15537
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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32.476M32.478M32.480M32.482M32.484M32.486M32.488M32.490M32.492M32.494M32.496M32.498M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions