Gene

CA1

Species
Homo sapiens
Symbol
CA1
Name
carbonic anhydrase 1
Synonyms
  • CA-I
  • CAB
Biotype
protein coding gene
Automated Description
Enables arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Predicted to be involved in one-carbon metabolic process. Located in extracellular exosome.
RGD Description
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18952
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          CA1 molecule type
          Interactor gene
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            Genetic Interactions

            CA1 role
            CA1 genetic perturbation
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