Gene

ERP29

Species
Homo sapiens
Symbol
ERP29
Name
endoplasmic reticulum protein 29
Synonyms
  • C12orf8
  • endoplasmic reticulum lumenal protein ERp28
Biotype
protein coding gene
Automated Description
Predicted to enable protein-folding chaperone binding activity. Involved in negative regulation of protein secretion and regulation of macromolecule metabolic process. Acts upstream of or within positive regulation of MAP kinase activity. Located in cell surface and endoplasmic reticulum.
RGD Description
This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12211
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            112.014M112.015M112.016M112.017M112.018M112.019M112.020M112.021M112.022M112.023M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ERP29 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              ERP29 role
              ERP29 genetic perturbation
              Interactor gene
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