Gene

MRPL24

Species
Homo sapiens
Symbol
MRPL24
Name
mitochondrial ribosomal protein L24
Synonyms
  • 39S ribosomal protein L24, mitochondrial
  • FLJ20917
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Part of mitochondrial large ribosomal subunit.
RGD Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12903
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusMrpl2410 of 10YesYes  
Rattus norvegicusmrpl2410 of 10YesYes  
Xenopus laevismrpl24.L1 of 1YesYes           
Xenopus tropicalismrpl245 of 9YesYes   
Danio reriomrpl2410 of 10YesYes  
Drosophila melanogastermRpL249 of 9YesYes   
Caenorhabditis elegansmrpl-249 of 9YesYes   
Saccharomyces cerevisiaeMRPL402 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
156.7375M156.7380M156.7385M156.7390M156.7395M156.7400M156.7405M156.7410M156.7415M156.7420M156.7425M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions

MRPL24 role
MRPL24 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
LEO1Homo sapiens
unspecified role
positive genetic interaction (sensu BioGRID)
  • Growth abnormality
PMID:30033366
unspecified role
MED24Homo sapiens
unspecified role
negative genetic interaction (sensu BioGRID)
  • Growth abnormality
PMID:30033366
unspecified role
MRPS5Homo sapiens
unspecified role
positive genetic interaction (sensu BioGRID)
  • Growth abnormality
PMID:30033366
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