Gene

ADAMTS12

Species
Homo sapiens
Symbol
ADAMTS12
Name
ADAM metallopeptidase with thrombospondin type 1 motif 12
Synonyms
  • A disintegrin and metalloproteinase with thrombospondin motifs 12
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
Biotype
protein coding gene
Automated Description
Enables metalloendopeptidase activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cellular response to growth factor stimulus; and protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix.
RGD Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13723
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            33.55M33.60M33.65M33.70M33.75M33.80M33.85M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ADAMTS12 molecule type
            Interactor gene
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              Genetic Interactions

              ADAMTS12 role
              ADAMTS12 genetic perturbation
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