Species

Homo sapiens

Symbol

OR5M8

Name

olfactory receptor family 5 subfamily M member 8

Synonyms

olfactory receptor 5M8
olfactory receptor OR11-194

Biotype

protein coding gene

Automated Description

Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane.

RGD Description

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR48018

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculus	Or5m8	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑
Rattus norvegicus	Or5m8	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
OR5M3	1	302	84	71	3 of 8	☑ ☐☐☐☐☑☑☐
OR5M9	2	306	82	68	3 of 8	☑ ☐☐☐☐☑☑☐
OR5M10	3	293	81	66	3 of 8	☑ ☐☐☐☐☑☑☐
OR5M1	4	293	81	66	3 of 8	☑ ☐☐☐☐☑☑☐
OR5M11	5	297	78	60	3 of 8	☑ ☐☐☐☐☑☑☐
OR8U1	6	299	72	56	3 of 8	☑ ☐☐☐☐☑☑☐
OR5AL1	7	308	69	54	3 of 8	☑ ☐☐☐☐☑☑☐
OR8U3	8	301	71	54	3 of 8	☑ ☐☐☐☐☑☑☐
OR5I1	9	314	68	52	3 of 8	☑ ☐☐☐☐☑☑☐
OR5AP2	10	302	70	54	3 of 8	☑ ☐☐☐☐☑☑☐
OR5B21	11	306	69	53	3 of 8	☑ ☐☐☐☐☑☑☐
OR8A1	12	306	69	52	3 of 8	☑ ☐☐☐☐☑☑☐
OR8I2	12	306	70	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR8D1	13	301	70	53	3 of 8	☑ ☐☐☐☐☑☑☐
OR8D4	14	309	67	52	3 of 8	☑ ☐☐☐☐☑☑☐
OR8J1	15	307	70	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR5B12	16	299	69	54	3 of 8	☑ ☐☐☐☐☑☑☐
OR5L1	17	308	67	53	3 of 8	☑ ☐☐☐☐☑☑☐
OR8U9	18	299	73	56	2 of 8	☐ ☐☐☐☐☑☑☐
OR8J3	19	306	69	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR8G1	20	305	68	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR8U8	21	299	72	55	2 of 8	☐ ☐☐☐☐☑☑☐
OR5L2	22	308	66	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR8B3	23	304	67	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR8K3	24	299	69	52	3 of 8	☑ ☐☐☐☐☑☑☐
OR8H2	25	306	67	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR5B2	26	301	68	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR5D18	27	307	66	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR8G5	28	306	67	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR5D14	29	308	67	49	3 of 8	☑ ☐☐☐☐☑☑☐
OR8B2	30	304	67	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR8B8	31	306	66	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR8K1	32	300	67	51	3 of 8	☑ ☐☐☐☐☑☑☐
OR5B3	33	299	67	52	3 of 8	☑ ☐☐☐☐☑☑☐
OR8H3	34	306	66	49	3 of 8	☑ ☐☐☐☐☑☑☐
OR9I1	35	301	67	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR8K5	35	301	67	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR8D2	36	293	69	52	3 of 8	☑ ☐☐☐☐☑☑☐
OR5AR1	37	307	70	50	2 of 8	☑ ☐☐☐☐☐☑☐
OR8H1	38	306	66	48	3 of 8	☑ ☐☐☐☐☑☑☐
OR5F1	39	306	68	52	2 of 8	☑ ☐☐☐☐☐☑☐
OR5D16	40	308	65	49	3 of 8	☑ ☐☐☐☐☑☑☐
OR9Q1	41	303	68	47	3 of 8	☑ ☐☐☐☐☑☑☐
OR5B17	42	306	66	47	3 of 8	☑ ☐☐☐☐☑☑☐
OR5W2	43	307	67	52	2 of 8	☑ ☐☐☐☐☐☑☐
OR8B12	44	302	65	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR5J2	45	304	68	51	2 of 8	☑ ☐☐☐☐☐☑☐
OR9G4	46	299	68	47	3 of 8	☑ ☐☐☐☐☑☑☐
OR5A2	47	302	70	50	2 of 8	☑ ☐☐☐☐☐☑☐
OR8B4	48	307	62	50	3 of 8	☑ ☐☐☐☐☑☑☐
OR9Q2	49	303	66	47	3 of 8	☑ ☐☐☐☐☑☑☐
OR5P3	50	311	67	49	2 of 8	☑ ☐☐☐☐☐☑☐
OR5AK2	51	306	66	46	3 of 8	☑ ☐☐☐☐☑☑☐
OR5D13	52	309	64	45	3 of 8	☑ ☐☐☐☐☑☑☐
OR5P2	53	314	65	47	2 of 8	☑ ☐☐☐☐☐☑☐
OR5AS1	54	311	66	47	2 of 8	☑ ☐☐☐☐☐☑☐
OR5A1	55	308	66	49	2 of 8	☑ ☐☐☐☐☐☑☐
OR5AU1	56	293	66	51	2 of 8	☑ ☐☐☐☐☐☑☐
OR5C1	57	300	67	47	2 of 8	☑ ☐☐☐☐☐☑☐
OR11L1	58	310	64	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5H2	59	305	64	45	2 of 8	☑ ☐☐☐☐☐☑☐
OR5H1	60	308	64	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5K1	61	304	62	47	2 of 8	☑ ☐☐☐☐☐☑☐
OR5K2	62	308	63	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5AN1	63	297	66	45	2 of 8	☑ ☐☐☐☐☐☑☐
OR6B2	64	303	64	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5AC2	65	297	64	46	2 of 8	☑ ☐☐☐☐☐☑☐
OR5K3	66	306	63	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR6Q1	67	309	61	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5H15	68	308	62	43	2 of 8	☑ ☐☐☐☐☐☑☐
OR5H14	69	299	65	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5H6	69	299	64	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR6B3	70	303	63	43	2 of 8	☑ ☐☐☐☐☐☑☐
OR10V1	71	302	64	42	2 of 8	☑ ☐☐☐☐☐☑☐
OR14A2	72	311	60	42	2 of 8	☑ ☐☐☐☐☐☑☐
OR13A1	73	303	61	44	2 of 8	☑ ☐☐☐☐☐☑☐
OR5K4	74	301	61	45	2 of 8	☑ ☐☐☐☐☐☑☐
OR6P1	75	303	61	42	2 of 8	☑ ☐☐☐☐☐☑☐
OR14A16	76	300	62	41	2 of 8	☑ ☐☐☐☐☐☑☐
OR10Q1	77	293	63	42	2 of 8	☑ ☐☐☐☐☐☑☐
OR14K1	78	305	57	40	2 of 8	☑ ☐☐☐☐☐☑☐
OR14C36	79	309	59	38	2 of 8	☑ ☐☐☐☐☐☑☐
OR14J1	80	302	56	40	2 of 8	☑ ☐☐☐☐☐☑☐
OR14I1	81	317	55	38	2 of 8	☑ ☐☐☐☐☐☑☐
OR10W1	82	296	56	36	2 of 8	☑ ☐☐☐☐☐☑☐
OR5AK3P	83				3 of 8	☑ ☐☐☐☐☑☑☐
OR8G2P	83				3 of 8	☑ ☐☐☐☐☑☑☐
OR8J2	84				2 of 8	☐ ☐☐☐☐☑☑☐
OR5AC1	84				2 of 8	☑ ☐☐☐☐☐☑☐
OR8G3	84				2 of 8	☐ ☐☐☐☐☑☑☐
OR5G3	84				2 of 8	☑ ☐☐☐☐☐☑☐
OR5D3P	84				2 of 8	☐ ☐☐☐☐☑☑☐

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

None

Other Sources

BioGRID CRISPR Screen Cell Line Phenotypes

No data available

Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

Chr11:56490435...56491370 - (0.94 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Category	Variant
NC_000011.10:g.56491090G>A	variant	rs146781106 SNP missense variant
NC_000011.10:g.56491124T>C	variant	rs148958538 SNP missense variant
NC_000011.10:g.56491315C>T	variant	rs146940313 SNP missense variant
NC_000011.10:g.56490476C>T	variant	rs576988751 SNP missense variant
NC_000011.10:g.56490898T>C	variant	rs142719978 SNP missense variant
NC_000011.10:g.56490586G>T	variant	rs1201233365 SNP missense variant
NC_000011.10:g.56490613G>T	variant	rs772332403 SNP missense variant
NC_000011.10:g.56491217C>G	variant	rs760153338 SNP missense variant
NC_000011.10:g.56490677C>G	variant	rs531125635 SNP missense variant
NC_000011.10:g.56490701T>G	variant	rs770196855 SNP missense variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location

Chr11:56490435...56491370 - (0.94 kb)

Assembly version

GRCh38

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

Transcript: Mode:

Expression

Primary Sources

None

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

4 interactor genes based on 4 annotations

OR5M8 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	CFTR	Homo sapiens	protein	protein complementation assay	biogrid:3586356	PMID:35156780
protein	RNF181	Homo sapiens	protein	affinity chromatography technology	biogrid:3103078	PMID:33961781
protein	UBE3A	Homo sapiens	protein	affinity chromatography technology	biogrid:3084559	PMID:33961781
protein	UNC45B	Homo sapiens	protein	affinity chromatography technology	biogrid:3124070	PMID:33961781

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Genetic Interactions

No data available