Gene

SERPINA6

Species
Homo sapiens
Symbol
SERPINA6
Name
serpin family A member 6
Synonyms
  • CBG
  • corticosteroid binding globulin
Biotype
protein coding gene
Automated Description
Enables steroid binding activity. Predicted to act upstream of or within glucocorticoid metabolic process. Located in extracellular exosome. Implicated in corticosteroid-binding globulin deficiency.
RGD Description
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11461
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusSerpina610 of 10YesYes  
Rattus norvegicusSerpina610 of 10YesYes  
Xenopus tropicalisserpina33 of 9YesNo   
Danio reriozgc:1742594 of 10YesYes  
Danio reriozgc:1138284 of 10YesYes  
Danio reriozgc:1742604 of 10YesYes  
Danio reriosi:ch211-186e20.74 of 10YesYes  
Danio rerioserpina14 of 10YesNo  
Danio rerioserpina1l4 of 10YesNo  
Danio rerioserpina74 of 10YesNo  
Drosophila melanogasterSpn28Dc3 of 9YesNo   
Drosophila melanogasterSpn88Eb3 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
SERPINA3142060454 of 8  
SERPINA1241559414 of 8  
SERPINA7343256403 of 8  
SERPINA5441260413 of 8  
SERPINA4537464453 of 8  
SERPINA2641257393 of 8  
SERPINA9737062453 of 8  
SERPINA11839159413 of 8  
SERPINA12936860353 of 8  
SERPINB91038054343 of 8  
SERPINB21141550303 of 8  
SERPINB41238854323 of 8  
SERPINB61337653343 of 8  
SERPINC11442149283 of 8  
SERPINI21538852323 of 8  
SERPINB131640650303 of 8  
SERPINB11738752313 of 8  
SERPINB31838952313 of 8  
SERPINA101939154283 of 8  
SERPINB82037951333 of 8  
SERPINB112139252283 of 8  
SERPINB122242247273 of 8  
SERPINB102339450283 of 8  
SERPINI12442047273 of 8  
SERPIND12537051323 of 8  
SERPINE32643245253 of 8  
SERPINF12737152283 of 8  
SERPINE22837251283 of 8  
SERPING12940447263 of 8  
SERPINF23038847283 of 8  
SERPINB53137950263 of 8  
SERPINB73236751253 of 8  
SERPINH13339546243 of 8  
SERPINE13436848273 of 8  
AGT3536245233 of 8  
HMSD3611357333 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Adult onset
Anemia
Asthenia
Autosomal dominant inheritance
Autosomal recessive inheritance
Decreased circulating cortisol level
Decreased urinary potassium
Fatigue
Hypertension
Hypokalemia
Showing 1 - 10 of 13 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
94.306M94.308M94.310M94.312M94.314M94.316M94.318M94.320M94.322M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000014.9:g.94314456T>Cvariant
SNP
  • missense variant
NC_000014.9:g.94304498T>Gvariant
SNP
  • missense variant
NC_000014.9:g.94309816C>Tvariant
SNP
  • synonymous variant
NC_000014.9:g.94314606T>Cvariant
SNP
  • missense variant
NC_000014.9:g.94314042A>Gvariant
SNP
  • missense variant
NC_000014.9:g.94309775C>Avariant
SNP
  • missense variant
NC_000014.9:g.94309791T>Avariant
SNP
  • missense variant
NC_000014.9:g.94309801C>Tvariant
SNP
  • missense variant
NC_000014.9:g.94314536C>Avariant
SNP
  • missense variant
NC_000014.9:g.94309955T>Avariant
SNP
  • missense variant
Showing 1 - 10 of 35 rows
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
94.306M94.308M94.310M94.312M94.314M94.316M94.318M94.320M94.322MENST00000341584.4 (SERPINA6)ENST00000555056.1 (SERPINA6)ENST00000557225.1 (SERPINA6)NM_001756.4 (SERPINA6)XM_047431827.1 (SERPINA6)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

14 interactor genes based on 21 annotations
SERPINA6 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
COCHHomo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
COCHHomo sapiens
protein
  • affinity chromatography technology
PMID:28514442
protein
COCHHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
COL4A2Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
DHFR2Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
DHFR2Homo sapiens
protein
  • affinity chromatography technology
PMID:28514442
protein
DHFR2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
FN1Homo sapiens
protein
  • affinity chromatography technology
PMID:23750785
protein
GET1Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
HLA-DPB1Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
Showing 1 - 10 of 20 rows
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Genetic Interactions

SERPINA6 role
SERPINA6 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
HAPSTR1Homo sapiens
unspecified role
positive genetic interaction (sensu BioGRID)
  • Growth abnormality, viability
PMID:33660365
Showing 1 - 1 of 1 rows
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