Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Biotype
protein coding gene
Automated Description
Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor receptor signaling pathway; regulation of platelet-derived growth factor receptor-alpha signaling pathway; and signal transduction. Predicted to act upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Located in cytosol and nucleoplasm. Implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Biomarker of lung squamous cell carcinoma and stomach carcinoma.
RGD Description
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]