Gene

LILRA4

Species
Homo sapiens
Symbol
LILRA4
Name
leukocyte immunoglobulin like receptor A4
Synonyms
  • CD85 antigen-like family member G
  • CD85g
Biotype
protein coding gene
Automated Description
Enables coreceptor activity and signaling receptor binding activity. Involved in Fc-epsilon receptor signaling pathway; negative regulation of cytokine production; and negative regulation of cytoplasmic pattern recognition receptor signaling pathway. Located in plasma membrane. Part of Fc-epsilon receptor I complex.
RGD Description
This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11738
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            54.334M54.335M54.336M54.337M54.338M54.339M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            LILRA4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              LILRA4 role
              LILRA4 genetic perturbation
              Interactor gene
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              Interactor role
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              Phenotype or trait
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